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Master Thesis

Choc anaphylactique à la succinylcholine : revue de la littérature, analyse descriptive d’une augmentation d’incidence

Abstract : In light of the recent emergence of a growing incidence and of an increasing number of notices to the pharmacovigilance of anaphylaxis shocks to succinylcholine in different French hospitals, this study provides an update on current knowledge about allergic shock to curare. It also provides an example of pharmacovigilance in France. This work makes a comparative analysis of the literature and research hypotheses that could explain this significant outbreak. Material and methods: this is a retrospective study of 19 cases of anaphylaxis to succinylcholine which occurred between 2010 and 2013 in two French university hospitals. Data from diagnostics, immediate biological and allergy tests were collected. Hemodynamic changes, ventilation, and the therapeutic management of these shocks were extracted from the consultations and anesthesia sheets. Results: 18 cases were validated. One case was withdrawn further to negative skin tests. Skin tests were not performed in two cases but these cases were kept on the basis of clinico-biological concordance and the absence of alternative diagnosis. A large proportion of severe shocks has been registered with 78% grade III and 22% grade IV. 39% patient’s had an allergic tendency. The injections were performed for 61% in the framework of scheduled surgery; for 28% in order to anticipate a difficult intubation; and for 61% because of inhalation risk or suspicion of full stomach. Bronchospasm and rash are often absent in favor of hemodynamic signs. Four hypotheses have been advanced to explain this outbreak.
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Master Thesis
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Submitted on : Friday, February 13, 2015 - 3:49:07 PM
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  • HAL Id : dumas-01116540, version 1


Clément Dauthier. Choc anaphylactique à la succinylcholine : revue de la littérature, analyse descriptive d’une augmentation d’incidence. Médecine humaine et pathologie. 2014. ⟨dumas-01116540⟩



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