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Master Thesis

Les anticorps monoclonaux comme biosimilaires thérapeutiques : cibles, modes d’actions et aspects pharmaco-économiques

Abstract : The development of monoclonal antibodies (mAb) brought new hope for treating incurable diseases or, in some cases, for replacing treatments with heavy side effects. The progress of this therapeutics was made possible through a constant development of production and control techniques that are increasingly mastered. The mAb option, with a single concept of target specificity, actually gave rise to a family of biosimilar therapeutics with similar mechanisms of action (ADCC / CDC / neutralization / function block) but acting on different targets. Despite some level of control of this family and with the benefit of hindsight of about a decade, therapeutic monitoring using laboratory tests have to be set up for some mAbs, or to be developed further for others, to ensure an effective therapeutic monitoring and improve the quality of care related to the use of biopharmaceuticals. This approach will certainly make savings in terms of cost, decreased side effects, prevention of accidents related to incompatibilities. These efforts must finally improve the patient quality life while increasing the rate of therapeutic success. From an economic point of view, this family of drugs is booming and will trustingly, in view of its current growth, gain significant market shares.
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Master Thesis
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Submitted on : Friday, June 19, 2015 - 5:07:59 PM
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  • HAL Id : dumas-01165683, version 1


Saad Charef-Eddine Nouar. Les anticorps monoclonaux comme biosimilaires thérapeutiques : cibles, modes d’actions et aspects pharmaco-économiques. Sciences pharmaceutiques. 2015. ⟨dumas-01165683⟩



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