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Master Thesis

Intoxications aiguës par baclofène : étude rétrospective descriptive d’une série de 28 cas à la Réunion et revue de littérature

Abstract : In a few years, baclofen appeared as a therapeutic alternative for alcoholic weaning. From 2012, questioned by the appearance of case of exposure in Reunion, french department strongly affected by alcoholism problems, we wished to make a current situation of the cases observed to understand the peculiarities of the exposed population, analyze the contexts of exposure as well as the future of these patients. The results of this descriptive study were obtained from the extraction of the data brought together by the network of toxicovigilance premises, between January 1st, and June 30th, 2014. 28 exposed cases were found. Nothingness in 2011, the number of cases listed afterward progresses significantly. The sex-ratio was 1 and the average age of the cases was 42,5 years. The suicidal nature concerned 85% of the exposures. 67% of patients had a medicinal suicidal history. Toxins associated were alcohol in 56% of the cases and medicine, in particular depressants of the central nervous system, in 60% of the cases. The supposed ingested dose average exceeded 300mg and was superior in 200 mg for 73% of the exposures. The first hours of care were marked by a coma for 50% of the cases and the convulsions showed themselves for 25% of the patients. The cardio-circulatory events concerned 20% of the patients. Similar omplications were found during the exposures isolated in baclofen. 50% of the patients were artificially ventilated on an average duration of 4,2 days. The hospitalizations lasted on average 6 days. No death was besides noticed. The observed data should allow making sensitive the medical community towards this molecule not divested of risks.
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Submitted on : Monday, July 20, 2015 - 11:29:23 AM
Last modification on : Wednesday, August 23, 2017 - 4:40:50 PM
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Benoit Baron. Intoxications aiguës par baclofène : étude rétrospective descriptive d’une série de 28 cas à la Réunion et revue de littérature . Médecine humaine et pathologie. 2015. ⟨dumas-01178491⟩

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