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Master Thesis

Le microchimérisme fœtal et son maintien Revue de la littérature

Abstract : Objective: To estimate through a review of the bibliography to what extent and which quantities a woman holds fetal cells or DNA in her body, after physiological or pathological pregnancy, at term or not. To determine what are the possible factors influencing passage and maintenance of fetal microchimerism. Materials and methods: Literature review conducted from december 2013 to July 2014 allowed a selection of 13 articles With the Keywords "fetal", "chimerism", "microchimerism", "post-partum" "delivery" and "persistence" in the PUBMED database. The 13 articles are detailed and analyzed in the current study. Results: Any woman Who has experienced pregnancy holds genetic tracks from her obstetric history. Either circulating fetal DNA and/or intact cells called pregnancy-associated progenitor cells can be found in the maternal circulation. Fetal microchimerism is kept in biological niches long term postdelivery ant its levels observed in maternal peripheral blood vary according to post-delivery time and to particular prior events such as interruption of pregnancy or to events happening post-delivery such as cancer, inflammation, etc. Conclusion: Microchimerism may play a role on health. Further studies are needed to precise its function and the reasons of its re-apparition long term after delivery. Could its monitoring be a predictive factor for disease diagnosis ?
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Submitted on : Monday, December 5, 2016 - 4:48:51 PM
Last modification on : Friday, October 23, 2020 - 4:37:40 PM
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  • HAL Id : dumas-01218759, version 1


Camille Sollier. Le microchimérisme fœtal et son maintien Revue de la littérature. Gynécologie et obstétrique. 2015. ⟨dumas-01218759⟩



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