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Master Thesis

Implication des facteurs périnataux dans le développement des Troubles du Spectre Autistique : cas particulier des naissances par césarienne programmée

Abstract : Worldwide, an estimate of 0.62% of children is diagnosed with Autism Spectrum Disorder (ASD) and the prevalence has increased considerably in the last decades. Genetics and environment including prenatal and perinatal factors have been suspected to interact in the causation of ASI). Recent report indicates that oxytocin-mediated neuroprotective yaminobutyric acid (GABA) exctitatory-inhibition shift during delivery is abolished in rodent models of autism. Programmed Caesarean Section (CS) is an obstetrical situation in which there is no oxytocin produced. Blocking oxytocin signaling in rat or mice mothers mimics this situation and produced offspring having electrophysiological and behavioral autistic-like features. Therefore the present work aimed at screening the literature for the perinatal factors associated to development of autism spectrum disorders with the special scope of programmed caesarean section. Delivery by CS is associated with a modest increased odd of ASD Specific impact of programmed CS is however poorly studied. Pooled Odd Ratio (OR) from few studies that reported adjusted estimates for elective CS was not significant. Given the growing prevalence of birth by programmed CS worldwide this warrants further investigation.
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https://dumas.ccsd.cnrs.fr/dumas-01218764
Contributor : École Universitaire de Maïeutique Marseille Méditerranée (eu3m) <>
Submitted on : Tuesday, December 6, 2016 - 11:19:25 AM
Last modification on : Monday, July 6, 2020 - 4:04:37 PM
Long-term archiving on: : Tuesday, March 21, 2017 - 2:20:59 AM

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  • HAL Id : dumas-01218764, version 1

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Claire Sunyach. Implication des facteurs périnataux dans le développement des Troubles du Spectre Autistique : cas particulier des naissances par césarienne programmée. Gynécologie et obstétrique. 2015. ⟨dumas-01218764⟩

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