Objectives: Concerns have been raised on non adherence behavior among patients with chronic inflammatory rheumatic diseases under biologics, which may be caused by various factors. The main objective of this study was to explain why patient discontinue their biologics by themselves. Methods: A quantitative and descriptive study was performed using a self-report questionnaire, which was sent via internet to different patients associations. Exploration of socio-demographic data, medical and therapeutic history, management of biologic's administration, previous experiences and patient's own resources were requested to explain self-discontinuation (SD). Results: A total of 581 patients answered to the questionnaire between 16 June and 4 July 2012, including 60.4% patients with Ankylosing Spondylitis (351/581), 33.7% with Rhumatoid Arthritis (196/581), 5.2% with Psoriatic Arthritis (30/581) and 0.7% with others CIRD (4/581). More than a thousand lines of biologics were described, with a median of 2 biologics per patients. Eighty-six patients experienced SD (14.8%). Factors which were significantly related to SD in univariate analysis were: more than one line of biologics, biologics longer than 3 years, self-administered biologics, experiences of side effects, consumption of alternative medicine, negative beliefs about treatment and lack of medical and social support. Logistic regression analysis also revealed low level of pain as a predictive factor of SD. Conclusions: These factors should be taken into consideration to better target patients who are more prone to discontinue their biologics by themselves, and to adapt our therapeutic patient education programs.