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Master Thesis

Adhésion aux recommandations sur la prévention et le traitement de l’ostéoporose dans le Lupus érythémateux systémique

Abstract : Objectives: To investigate compliance rates with the recommendations published in 2003 by the French National Authority for Health (HAS), in SLE, on the prevention and treatment of glucocorticoid-induced osteoporosis (GIOP) in the Bordeaux University Hospital. Methods: A cross-sectional study was performed on 109 patients with SLE, from May 2014 to November 2014, in the Departments of Rheumatology and Internal Medicine of the Bordeaux University Hospital. Results: Of the hundred and nine patients identified with SLE, 21 (19%) patients had indication for anti-osteoporotic treatment. These 21 patients were older (54±19 years) than the patients without indication to be treated and more women were menopaused (77%).They had a long-term use of corticosteroid (103.7±87.7 months) and a higher dose (9.9±9.6 mg/d), as well as greater use of immunosuppressant (81%). Among these 21 patients, 12 patients were received an anti-osteoporotic treatment. The recommendations were followed for 57% of patients, 71% received a supplementation of vitamins D and calcium and 86% underwent a bone mineral densitometry. Doing the same analyses with the new recommendations published in 2014, 30 (27%) patients should have been treated and 12 patients were received an anti-osteoporotic treatment. The recommendations were followed for 40% patients. Conclusion: The prevention and treatment of osteoporosis in SLE is still suboptimal. It is important that practitioners become aware of the importance of managing complications induced by the disease itself and also the treatments used, in particular musculoskeletal complications and osteoporosis.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-01244366
Contributor : Bu Carreire Université de Bordeaux <>
Submitted on : Tuesday, December 15, 2015 - 4:23:10 PM
Last modification on : Wednesday, August 23, 2017 - 4:33:20 PM
Long-term archiving on: : Saturday, April 29, 2017 - 3:13:13 PM

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Alexia Hourdille. Adhésion aux recommandations sur la prévention et le traitement de l’ostéoporose dans le Lupus érythémateux systémique. Médecine humaine et pathologie. 2015. ⟨dumas-01244366⟩

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