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Master Thesis

Intérêt de la TEP/TDM au 18-FDG dans le bilan d'extension initial et le suivi du mélanome muqueux nasaux-sinusien

Abstract : OBJECTIVE: To assess the value of 18-FDG PET/CT in initial work-up and follow-up of sinonasal melanoma. MATERIAL AND METHODS: Retrospective study realised on 20 patients traited in Bordeaux University Hospital between 2005 and 2015. Clinical, conventionnal imaging, PET/CT and histological data was collected and correlated. For each case, the value of PET/CT to detect tumoral site, lymph node extension and distant metastasis was evaluated measuring the SUV. A cut off of 2 was used. RESULTS: 38 PET/CT exams were performed (12 for initial staging and 26 for restating). On tumoral site,100% of tumors diagnosed on conventional imaging was detected whatever the time of realisation of the exam. We had 12% of false positive. On cervical lymph nodes, 23% of fixations was false positive.There was only one false negative. PET/CT detected distant metastasis in 45% of cases. There were no statistically significant differences between SUV on different locations neither in the moment of realization of the exam. DISCUSSION: PET/CT permits us to change therapeutic attitude in case of discovery of distant metastasis in 20% of cases. Nevertheless, it seems to overestimate lymph nodes extension and have to be compared to conventional imaging. CONCLUSION: PET/CT is a usefull exam for distant extension of sinonasal mucosal melanoma. Lymph nodes fixations may be carefully interpreted.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-01246635
Contributor : Bu Carreire Université de Bordeaux <>
Submitted on : Friday, December 18, 2015 - 6:52:40 PM
Last modification on : Wednesday, August 23, 2017 - 4:32:43 PM
Long-term archiving on: : Saturday, April 29, 2017 - 10:42:55 PM

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Dorothée Dunion. Intérêt de la TEP/TDM au 18-FDG dans le bilan d'extension initial et le suivi du mélanome muqueux nasaux-sinusien. Médecine humaine et pathologie. 2015. ⟨dumas-01246635⟩

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