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Master Thesis

Contrôler la plasticité du cortex cérébral adulte à travers l'action non-autonome de l'homéoprotéine Otx2

Abstract : Critical periods of plasticity during early postnatal brain developpement shapes neuronal circuits in response to the environment. Preferential transfer of Otx2 in parvalbumin-positive interneurons leads to their maturation and to their opening of a critical period. During my internship, we confirmed that: the accumulation of Otx2 in parvalbumin-positive interneurons involves an interaction between Otx2 and CS-E in the glycosaminoglycan-enriched extracellular matrix. Moreover, we observed that the maturation of parvalbumin-positive cells entails a modification of epigenetic marks; suggesting the critical period leads to dramatic modifications of heterochromatin structure.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-01266848
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Submitted on : Wednesday, February 3, 2016 - 2:51:18 PM
Last modification on : Tuesday, June 15, 2021 - 2:57:10 PM
Long-term archiving on: : Saturday, November 12, 2016 - 6:23:16 AM

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  • HAL Id : dumas-01266848, version 1

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Damien Testa. Contrôler la plasticité du cortex cérébral adulte à travers l'action non-autonome de l'homéoprotéine Otx2 . Sciences du Vivant [q-bio]. 2015. ⟨dumas-01266848⟩

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