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Master Thesis

Les lymphocytes T régulateurs, biomarqueurs du contrôle de l’asthme chez l’enfant atteint d’asthme sévère allergique traité par omalizumab

Abstract : Allergic asthma is an inflammatory disease of the lungs. The inflammation is associated with an abnormality of the Th1 / Th2 balance towards Th2 lymphocytes. The deficit in regulatory T cells (Treg) could be responsible for this anomaly. Omalizumab is a monoclonal antibody directed against IgE used as additional treatment in severe asthma. The objective of our study is to assess the level of circulating Treg (assessed by marking FoxP3) as a marker of efficacy of omalizumab in relation to asthma control. We conducted a longitudinal study, prospective, single-center in children with allergic severe asthma, uncontrolled on maximum salary. We noted before (day 0) and at 16 weeks (day1) of treatment with omalizumab: the control of asthma, EFR, a dosing eosinophils and Treg evaluated by FoxP3. 21 patients were included. The rate of uncontrolled patients was 95.2% at D0 and 4.8% at D1 (p = 0.0076). The percentage of Tregs increased significantly between D0 and D1 (p = 0.026) and the rate of eosinophils decreased significantly (p = 0.013). The evolution of the control of "uncontrolled" in "controlled" at D1 was explained by Treg single variable (p = 0.002) independently of other factors. In our population, treatment with omalizumab improves asthma control. The improvement of the control is associated with a significant increase in Treg. The rate of Treg cells is associated with the control of asthma and represents a novel biomarker of efficacy of omalizumab.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-01306266
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Submitted on : Friday, April 22, 2016 - 4:13:14 PM
Last modification on : Friday, March 27, 2020 - 2:21:44 AM
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  • HAL Id : dumas-01306266, version 1

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Pauline Benier-Tallon. Les lymphocytes T régulateurs, biomarqueurs du contrôle de l’asthme chez l’enfant atteint d’asthme sévère allergique traité par omalizumab. Médecine humaine et pathologie. 2015. ⟨dumas-01306266⟩

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