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Master Thesis

Complications vasculo-placentaires chez les femmes enceintes infectées par le VIH : une étude cas-témoin

Abstract : Background: Data from international literature suggest a link between HIV infection and placental vascular complications during pregnancy. Current studies on the subject are conflicting. Objective: The aim of the study was to evaluate the incidence of placental vascular complications during pregnancy among HIV+ and HIV- patients. Study Design: It is a single-center case-control study comparing the rates of gestational hypertension, preeclampsia, eclampsia and vascular intrauterine growth retardation from 280 HIV+ and 560 HIV- patients matched by age, parity and geographical origin. Results: The rate of placental vascular complications was not statistically different between HIV+ and HIV- patients: 7.5% vs 9.8%, respectively (p = 0.27). HIV+ patients have a significant increase in overall prematurity rate: 18.6% vs 8.0%, p <0.0001 and a significant decrease in birthweight for gestational age: 41.6th percentile vs 46.6th percentile, p = 0.02. Conclusion: This study does not observe difference in the incidence of placental vascular complications between HIV + and HIV- patients. The significant increase in prematurity and low birth weight among HIV + patients has to be explored by further specific studies.
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Master Thesis
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  • HAL Id : dumas-01470121, version 1

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Geoffroy Canlorbe. Complications vasculo-placentaires chez les femmes enceintes infectées par le VIH : une étude cas-témoin. Médecine humaine et pathologie. 2012. ⟨dumas-01470121⟩

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