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Master Thesis

Mort subite de l’adulte : une série de 534 autopsies médico-légales avec comparaison hommes-femmes

Abstract : Between 1985 and 2009, in the department of pathology and forensic medicine in Raymond Poincaré hospital in Garches, 534 autopsies were performed on adult victims of sudden death : 165 women and 369 men, all 18 years old or more. For each case, a complete forensic autopsy was performed, with toxicology and histology. Sex, age, place of death, physical or psychological stress, delay between the symptom onset and death, cardiopulmonary resuscitation, time of death, heart weight, cause of death and degree of certitude of the diagnosis were reported retrospectively for each case. The epidemiologic profile was compared according to gender. Sudden death occured more frequently at home in women (80%) than in men (47%). A cardiac cause of death was reported in 61,0% of the cases. The leading cause of death was coronary artery disease in men (43,6%), cardiomyopathies in women (18,8%), mainly right ventricular cardiomyopathy (87,1% of the cardiomyopathies vs 40,4% in men). The non-cardiac causes of death were mainly respiratory or neurologic, again occurring more frequently in women (17,6% and 16,4% in women, vs 9,9% and 10,3% in men). In 4,3% of cases, the cause of death was undetermined. Unexplained deaths were attributed mainly to cardiac channelopathies. Molecular biology techniques are being tried out to continue the investigations whenever a diagnosis could not be set from a complete autopsy protocol.
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Master Thesis
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Anne-Laure Naneix. Mort subite de l’adulte : une série de 534 autopsies médico-légales avec comparaison hommes-femmes. Médecine humaine et pathologie. 2012. ⟨dumas-01472440⟩

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