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Master Thesis

Syndrome de Gilles de la Tourette et thérapeutiques : revue de littérature

Abstract : Tourette syndrome (TS) is a chronic neurodevelopmental disorder characterised by motor tics and at least one vocal tic, lasting more than one year, with onset before adulthood. Its main comorbidities are psychiatric : Attention Deficit Hyperactivity Disorder (ADHD) and Obsessive Compulsive Disorder (OCD). Treatment choices are complicated by high clinical heterogeneity amongst patients. We have conducted a literature review to determine today's best treatment options for TS depending on the clinical picture. Psychotherapies including Comprehensive Behavioral Intervention for Tics (CBIT) and Exposure Response Prevention (ERP) are effective in patients with mild tics. Pharmacotherapy is required if psychotherapy fails or in the case of disabling tics. Aripiprazole is the first-line anti-tic agent for both its efficiency and accepted tolerance. Other neuroleptics such as risperidone and pimozide are to be considered in case of poor results with aripiprazole. Finally, functionally disabling tics resistant to psychotherapy and pharmacotherapy are an indication for surgical treatment and deep brain stimulation (DBS).
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Master Thesis
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Contributor : Bu Carreire Université de Bordeaux <>
Submitted on : Saturday, April 1, 2017 - 12:07:21 PM
Last modification on : Wednesday, August 23, 2017 - 4:41:43 PM
Long-term archiving on: : Sunday, July 2, 2017 - 12:48:05 PM


  • HAL Id : dumas-01499890, version 1



Xavier Henry. Syndrome de Gilles de la Tourette et thérapeutiques : revue de littérature . Médecine humaine et pathologie. 2017. ⟨dumas-01499890⟩



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