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Master Thesis

Neuroblastome : intérêt et valeur pronostique de la scintigraphie 123I-MIBG post-opératoire

Abstract : INTRODUCTION : Post-surgical scintigraphy is of importance to assess residual tissue at surgical site in neuroblastoma. GOALS : 1. to compare 123I-MIBG SPECT/CT acquisition to 123I-MIBG planar scintigraphy. 2. to assess the impact of MIBG uptake in residual tissue on outcome. PATIENTS AND METHODS : Thirty patients operated for neuroblastoma were consecutively included between august 2012 and july 2015. Completeness of surgery was assessed on operative report. One month post-operative imaging included 123IMIBG scintigraphy with SPECT/CT and planar acquisitions and morphological exams. A visual analysis and semi-quantification of 123I-MIBG SPECT/CT were performed. RESULTS : Median follow-up was 20 months (range 6-80). Median 20-months progressive disease interval was 76.7%. Surgery was considered as complete in 23 patients and incomplete in 7 patients. Fifteen (50%) patients had positive morphological exam on surgical site. Nine of these 15 patients had negative MIBG scintigraphy. Six (20%) patients had positive 123IMIBG scintigraphy (3 on planar acquisitions and 6 on SPECT/CT) and 24 patients had negative 123I-MIBG scintigraphy. Five of the 6 patients (83%) with positive 123I-MIBG scintigraphy presented progressive disease. None of the 6 patients patient who had a complete surgery and a negative 123I-MIBG scintigraphy but a positive morphological imaging had progressive disease. Positivity of planar and SPECT/CT 123I-MIBG scintigraphy was significant predictors for progression free survival. CONCLUSION : Post-surgical 123IMIBG SPECT/CT appears a key tool to assess residual tissue in neuroblastoma. Further studies are needed to assess impact for patient’s management.
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Master Thesis
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Submitted on : Thursday, May 18, 2017 - 10:39:03 AM
Last modification on : Friday, March 27, 2020 - 2:44:40 AM


  • HAL Id : dumas-01524437, version 1


Matthieu Breton. Neuroblastome : intérêt et valeur pronostique de la scintigraphie 123I-MIBG post-opératoire. Médecine humaine et pathologie. 2016. ⟨dumas-01524437⟩



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