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Master Thesis

Étude de la tolérance glucidique dans la cohorte réunionnaise des patients atteints de la mucoviscidose

Abstract : Objective: Reunion Island, a French overseas territory of 852,000 inhabitants, has a higher prevalence of cystic fibrosis than French national prevalence, with specific genetic characteristics. The objective was to describe a cohort of patients with cystic fibrosis, in Reunion Island, in terms of their glucose tolerance disorders.Methods : an observational, retrospective study included exhaustively patients with cystic fibrosis disease managed in 2 reference centers, in Reunion Island, between September 2016 and March 2017. Their glucose tolerance profile was determined by using their Oral Glucose Tolerance Test (OGTT). Results: 117 patients were included, including 52 women, aged 0-56 years (mean age 14.59 years). The prevalence of cystic fibrosis is estimated at 13.73 per 100,000 people. 20 patients (17.1%) have cystic fibrosis-related diabetes, 33 (28.2%) have impaired glucose tolerance (IGT), 28 (23.9%) had normal glucose tolerance (NGT), 34% of those over 18 years are were patients with diabetes. Y122X is a mutation of class 1 specific to the island, 43 patients (36.75%) were carriers of that mutation. There was no relationship between the mutation Y122X and glucose tolerance. There was no relationship between of Y122X on carbohydrate tolerance. 36 patients (30.8%) did not had an OGTT because of their young age. The mean age at diagnosis of diabetes was 18.3 years [9.2-34.9], 9 patients with diabetes were on insulin injection and 3 were on hypoglycaemic sulfonamide. None of the 33 patients, with impaired glucose tolerance, were on insulin or hypoglycaemic sulfonamide. Some patients received continuous glucose monitoring for diagnostic and therapeutic purposes. Conclusion: the prevalence of cystic fibrosis-related diabete, in Reunion Island, was close to the French national prevalence, despite having a genetic specific population. The use of new technologies in diabetes opens new perspectives.
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Master Thesis
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Contributor : Bu Carreire Université de Bordeaux <>
Submitted on : Monday, July 24, 2017 - 2:13:27 PM
Last modification on : Thursday, October 26, 2017 - 1:13:02 AM


  • HAL Id : dumas-01567746, version 1



Marie Hoarau. Étude de la tolérance glucidique dans la cohorte réunionnaise des patients atteints de la mucoviscidose. Médecine humaine et pathologie. 2017. ⟨dumas-01567746⟩



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