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Master Thesis

Analyse des mouvements oculaires saccadiques à la phase prodromale de la maladie d’Alzheimer

Abstract : Objective. The aim of our study was to examine saccadic eye movements through several paradigms in patients with prodromal Alzheimer's disease (PAD) compared with patients suffering from mild to moderate Alzheimer's disease (AD) and aged-matched controls. Methods. We recorded eye movements by automated infrared eye-tracking in 79 patients (PAD: 29, AD: 23, controls: 27). The reflex saccades (horizontal gap and vertical step paradigms) and voluntary (antisaccades (AS), spatial decision and prediction paradigms) were studied. All subjects also received a neuropsychological test battery. We studied the correlations between the AS error rate and the neuropsychological scale scores. Results. PAD patients showed more AS directional errors compared to the control group (46.9%, standard deviation 25.9% versus 24.3%, standard deviation 19.8%, p = 0.0007). AS initiation latency was higher in PAD patients than in AD patients (p = 0.0335). Execution parameters of the saccades (precision, velocity, latency) were globally not altered. AS errors percentage was correlated with most of neuropsychological tests, including the Mini-Mental State Examination. In general, correlations were weak to moderate. Conclusion. It seems that there exists a "pattern" of saccadic execution detectable by automated analysis at an early stage of AD. Quick and easy, saccades exploration may constitute a new diagnosis biomarker of prodromal AD.
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Master Thesis
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Contributor : Bu Carreire Université de Bordeaux <>
Submitted on : Friday, September 29, 2017 - 12:01:52 PM
Last modification on : Thursday, October 19, 2017 - 1:14:58 AM
Long-term archiving on: : Saturday, December 30, 2017 - 1:41:34 PM


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Alexandre Cosnard. Analyse des mouvements oculaires saccadiques à la phase prodromale de la maladie d’Alzheimer. Médecine humaine et pathologie. 2017. ⟨dumas-01598098⟩



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