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Master Thesis

Facteurs cliniques et radiologiques associés aux complications graves des fasciites nécrosantes cervicales

Abstract : Cervical necrotizing fasciitis (CNF) is a severe and debilitating disease that requires intensive care unit (ICU) management and prompt surgical treatment to reduce morbidity and mortality. The aim was to estimate the incidence and factors associated with severe complications of CNF. We reviewed the medical records of consecutive patients hospitalized in an ICU from 2007 to 2012. The data were collected retrospectively; cervical and thoracic computed tomography (CT) scans, performed on admission, were reviewed by an experienced and blinded radiologist to determine CNF complications. A cohort of 160 patients was included. The following complications of CNF were found: bilateral extension of CNF (28 %), internal jugular vein thrombosis (21 %), descending necrotic effusion (14 %), mediastinitis (24 %), and mortality (4 %); 48 % had at least one cervical complication. The significant independent factors are odynophagia, dyspnea, oral glucocorticoids intake before admission, and pharyngeal source. Oral nonsteroidal anti-inflammatory drug intake before admission does not have any impact. The initial CNF complications increased both the duration of mechanical ventilation and the length of stay in the ICU. On the basis of a multivariate analysis, the independent factors for severe complications are pharyngeal CNF and oral glucocorticoid intake before admission. Our study demonstrated that an initial cervico-thoracic CT scan revealed a high incidence of cervical and mediastinal CNF complications that all needed immediate management. Those severe complications might be avoidable as they were associated, with prehospital oral glucocorticoid intake.
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Master Thesis
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Submitted on : Monday, November 6, 2017 - 5:49:16 PM
Last modification on : Friday, March 27, 2020 - 2:44:31 AM


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  • HAL Id : dumas-01629782, version 1


Hélène Nougue. Facteurs cliniques et radiologiques associés aux complications graves des fasciites nécrosantes cervicales . Médecine humaine et pathologie. 2016. ⟨dumas-01629782⟩



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