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Master Thesis

Rechute cytologique de Leucémie Aiguë Myéloblastique en post allogreffe : une étude rétrospective monocentrique

Abstract : Allogeneic haematopoietic stem cell transplantation (HSCT) is a curative option for acute myeloid leukaemia (AML). A major improvement of conditioning regimen has been realized in the last two decades. Unfortunately, relapse remains the main cause of death. Only few studies analyzed the survival of patients presenting with post-HSCT AML relapse and their treatment options. The purpose of this study was to analyze the survival of patients with post-HSCT AML relapse, to describe the treatment options and to search for factors associated with poor prognosis at relapse. In this study, we collected the data on all patients transplanted between January 2005 and December 2014 and showing AML relapse after HSCT. 100 patients relapsed with a median time from transplant of 123.5 days (11-2726 days). The 1 and 2 year overall survival rate was 24% and 13% respectively. Seven patients responded to immunosuppression tapering and 19 patients to first line treatment containing radiotherapy, chemotherapy and or DLI (Donor Lymphocyte Infusion). Patients receiving an association of chemotherapy and DLI showed a better response and a better survival compared to chemotherapy alone. Patients with FLT3 mutation did not respond to conventional treatment. Factors leading to better survival at relapse were age, gender and treatment response. This study confirmed the severity of AML relapsing after HSCT.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-01652003
Contributor : Bu Carreire Université de Bordeaux <>
Submitted on : Wednesday, November 29, 2017 - 6:12:05 PM
Last modification on : Saturday, December 9, 2017 - 1:16:55 AM

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Clémence Mediavilla. Rechute cytologique de Leucémie Aiguë Myéloblastique en post allogreffe : une étude rétrospective monocentrique . Médecine humaine et pathologie. 2017. ⟨dumas-01652003⟩

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