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Master Thesis

La saisonnalité et l’horloge biologique dans les troubles bipolaires

Abstract : Bipolar disorders (BD) are severe psychiatric disorders of multifactorial origin with very heterogeneous clinical presentations. BD with seasonal characteristics (CS +) are of major interest because this pattern is frequent, recurrent and associated with more severe BD clinical characteristics and outcomes. My thesis objective is to identify biomarkers associated with CS in BD. My hypothesis is that there is a global vulnerability of the biological clock in these patients with BD, with both circadian and infradian abnormalities. I assessed circadian rhythms and sleep patterns of patients with BD CS + in remission, compared with remitted patients CS- and healthy control subjects, using self - questionnaires and actigraphy. The univariate analysis showed that CS + patients, compared to CS- and control subjects, had a significantly longer sleep latency. CS + patients, compared to CS-, had daytime sleepiness and were significantly more frequently treated with lithium and Atypical Antipsychotics (APA). Univariate analysis showed no differences in phase markers (CSM, M10 onset, L5 onset), stability markers (CTI FR, inter-day stability) and circadian rhythms amplitude (CTI LV, Amplitude activity). The logistic binary regression retained the effect of lithium and APA on CS. We did not observe abnormalities of the circadian rhythms and sleep associated with CS in patients with BD. Nevertheless this work paves the way for future research as assessing the effect of the lithium and the APA on infradian rhythms.
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Master Thesis
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Submitted on : Friday, April 6, 2018 - 11:20:15 AM
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  • HAL Id : dumas-01760358, version 1


Julia Maruani. La saisonnalité et l’horloge biologique dans les troubles bipolaires . Médecine humaine et pathologie. 2017. ⟨dumas-01760358⟩



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