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Master Thesis

Description des crises d’angioedème motivant un appel sur le téléphone d’astreinte du centre de référence des angioedèmes à kinines

Abstract : Introduction: Angioedema (AE) are acute, localized subcutaneous swellings that regress over hours or days. Their severity and treatment differ depending on the underlying cause: histamin or bradykinin mediated angioedema. To this date, no reliable diagnostic tests are available to rapidly differentiate these forms of AE. Objective: This study aimed to describe the possible clinical diagnosis of an AE episode after a call on the french national reference centre for AE(CREAK) hotline. Methods: Physicians calling on the CREAK hotline were asked to fill a clinical description form for the AE episode. Patients were classified in the groups AE in the presence of a renin-angiotensin blocker (AESRAA), mast cell mediated AE (MC-AE) and bradykinin mediated AE in the absence of a renin-angiotensin blocker (AEB). Results: 88 patients were included. 41 (48.8%) in the AESRAA group, 39 (46.4%) in the MC-AE group, and 4 (4.8%) in the AEB group. The patients in the AESRAA group had more lingual and respiratory AE, and a tendency (p=0.057) to more frequently require monitoring in an intensive care unit. Conclusion: This study highlights the importance of AE in the presence of a SRAA blocker. The absence of diagnostic criteria or tests of these forms of AE make the use of costly and restricted treatments unavoidable.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-01896397
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Submitted on : Tuesday, October 16, 2018 - 10:15:36 AM
Last modification on : Wednesday, July 15, 2020 - 8:58:04 AM
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Nicolas Simon. Description des crises d’angioedème motivant un appel sur le téléphone d’astreinte du centre de référence des angioedèmes à kinines. Médecine humaine et pathologie. 2018. ⟨dumas-01896397⟩

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