Influence du microbiote intestinal sur la régulation du comportement alimentaire

Abstract : The intestinal microbiota, a long-neglected organ, has recently been the subject of extensive research since the advent of the new molecular techniques permitting its identification. He is in close mutual association with the host and his involvement in animal and human pathophysiology is much wider than imagined. In the field of nutrition, considerable progress on knowledge of microbiota’s physiological functions have enabled the conception’s evolution of homeostatic regulation of dietary behavior toward an integrative model including intestinal microbiota as a fully-fledged actor. Thus, the imbalance of this ecosystem, or intestinal’s dysbiosis, is described in the literature as a triggering factor, aggravating and/or perpetuating the eating disorders. Because of their ever-increasing prevalence in the general population and their numerous comorbidities, the latter constitutes a serious public health issue, requiring a better physiopathological understanding and new etiopathogenic treatments. More generally, the gut microbiota represents a considerable field of research, which now paves the way for new treatment tracks based on bidirectional host-microbiota interactions, ranging from the use of pre- / probiotics to fecal microbiota transplantation, through the development and validation of biomarkers putting the microbiota at the heart of tomorrow's predictive nutrition.
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Master Thesis
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Submitted on : Monday, November 19, 2018 - 11:36:31 AM
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Lucie Deceuninck. Influence du microbiote intestinal sur la régulation du comportement alimentaire. Sciences pharmaceutiques. 2018. ⟨dumas-01926455⟩

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