Comparaison du TTR (Time in Therapeutic Range) des INR des patients traités par warfarine versus fluindione

Abstract : Introduction: Venous Thrombo-Embolism (VTE) and Non-Valvular Atrial Fibrillation are two diseases requiring anticoagulation for which warfarin and especially fluindione are the most commonly used in France with a target INR between 2 and 3. The percentage of time patients are within this range - the TTR (Time in Therapeutic Range) - is used to assess the quality of anticoagulation control. The main objective of our study was to compare the TTR of patients treated with warfarin with those treated with fluindione. Methods: Retrospective, analytical and observational study. The INR results of each patient were extracted from the database of the Gen-Bio laboratory in Clermont-Ferrand during the period from January 1 to December 31, 2017. The data collection has been made anonymous. The inclusion criteria were any patient treated with warfarin or fluindione with an INR objective between 2 and 3. The TTR was calculated for each patient using the Rosendaal method for comparison purposes. Results: A total of 5153 patients were included. Patients in the warfarin group were 2 years older (p<0.001). In both groups there were more men (p=0.). The TTR of patients treated with warfarin was 71.7% and that of patients treated with fluindione was 71.6%. Patients under 40 years of age in the warfarin group had a higher TTR than those in the fluindione group (80.1% versus 63.9%; p=0.) 29% of patients in both groups performed less than 6 blood tests (p=0.) in the year responsible for a worse TTR (p=0.). Conclusion: There is no significant difference in the INR balance between warfarin and fluindione except in men and patients under 40 years of age.
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Matthieu Lemaire. Comparaison du TTR (Time in Therapeutic Range) des INR des patients traités par warfarine versus fluindione. Sciences du Vivant [q-bio]. 2018. ⟨dumas-02099790⟩

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