Intérêt du dépistage du syndrome d'apnées du sommeil chez les malades rénaux chroniques

Abstract : INTRODUCTION. Sleep apnea (SA) has an increased prevalence. Some conditions are associated with high prevalence of SA, like hypertension, diabete mellitus or obesity. Patients with chronic kidney disease (CKD) are not part of high risk-populations in french guidelines .This study aimed to determine the prevalence of SA in patients with CKD and his link with CKD severity in a Reunion Island hospital. MATERIAL AND METHOD. We retrospectively studied patients with CKD from stage 1 to 4 based on EDTA-measure of GFR, who underwent a night polygraphy recording. SA was defined as an Apnea-Hypopnea Index (AHI) score ≥ 5 /H of sleep. RESULTS. 133 patient with chronic kidney disease from stage 1 to 4 where selected. A SA was found in 68 patients (51%). SA was predominantly obstructive (n = 60) and 47 patients (35%) had a moderate or severe SA (AHI > 15/ H). Male sex and age was significantly associated with SAS in univariate analysis. GFR was lower in the SA group than in the non-SA group (47.8 ± 19.6 vs. 59 ± 21.16 ml/min/1.73 m2, p <0.01), and we found a correlation between elevation of AHI and GFR decline. There was no impact of SA on annual GFR decrease. CONCLUSION. We found a high prevalence of SA in our population and SA severity seems correlated to CKD severity. A prospective study should be conducted to find SA predictors in patients with CKD and his consequences on renal function and CKD progression.
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Master Thesis
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Laurie Masse. Intérêt du dépistage du syndrome d'apnées du sommeil chez les malades rénaux chroniques. Sciences du Vivant [q-bio]. 2019. ⟨dumas-02129578⟩

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