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Master Thesis

Le dépistage prénatal non invasif : état des lieux après une année de pratique au CHU de Caen

Abstract : Objective : review of the changes made by NIPT in the screening of Down Syndrome, trisomy 18 and 13 and description of NIPT’s performance in the UHC of Caen in 2017. Methods : descriptive and retrospective study : 475 patients who underwent the NIPT for the period of january 1st, 2017 to december 31th, 2017. Results : the NIPT leads to the screening of 3 Down Syndrome thanks to the extend of the maternal serum markers risk threshold and the availability of this screening for the twin pregnancies. The number of amniocenteses significantly decreased in 2017. We have not seen significant increase of Down Syndrome, T18 or T13 diagnosed. The NIPT results showed a specificity of 100% for Down Syndrome, T18 and T13, a sensibility of 85,7% and a false positive rate of 14,7% for Down Syndrome. A sensibility of a null value for T13 and T18. Conclusion : the NIPT provide better performance screening for Down Syndrome.
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https://dumas.ccsd.cnrs.fr/dumas-02176988
Contributor : Muriel Pelletier-Guichard <>
Submitted on : Monday, July 8, 2019 - 3:22:04 PM
Last modification on : Friday, October 23, 2020 - 4:59:58 PM

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Marine Lemesle. Le dépistage prénatal non invasif : état des lieux après une année de pratique au CHU de Caen. Gynécologie et obstétrique. 2019. ⟨dumas-02176988⟩

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