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Master Thesis

Traitement des néoplasies intraépithéliales génitales par laser CO2 : étude rétrospective au CHU de Caen

Abstract : Introduction: genital intraepithelial neoplasia (NIE) are precursors of squamous cell carcinoma. Ideal treatment must be efficient, conservative and well tolerated. CO2 laser is one of the recommended treatment, but its efficiency and its tolerance have not been much studied. Material and methods: it is a retrospective and monocentric study. Sixteen patients (8 women and 8 men) treated with CO2 laser for a genital IEN, high-grade or differentiated, have been included. Clinical laterals margins taken during treatment were 3 to 5 mm. The CO2 laser session, the therapeutic response’s assessment and follow-up have been undertaken by a dermatologist from the University Center Hospital of Caen. Results: patients’ mean age was 68.1 years old with a mean follow-up of 52.7 months (5-130). The lesions were unique for 87,5% of patients. Recurrence rate of vulvar intraepithelial neoplasia (VIN) after CO2 laser treatment were 58% and 40% for men. There was no impact on the patients’ quality of life or any modifications of sexual activity for more than 90% of them. Conclusion: whatever are the recommended treatments for intraepithelial neoplasia, recurrences are frequent. CO2 laser is a conservative therapeutic option, effective and well tolerated. It allows to obtain a fast clinical remission, but as all available treatments, a long-term dermatologic follow-up remains necessary.
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Master Thesis
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Submitted on : Monday, September 30, 2019 - 12:51:39 PM
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  • HAL Id : dumas-02301310, version 1


Élisa Joly. Traitement des néoplasies intraépithéliales génitales par laser CO2 : étude rétrospective au CHU de Caen. Médecine humaine et pathologie. 2019. ⟨dumas-02301310⟩



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