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Master Thesis

Facteurs prédictifs de passage de la sclérose en plaques récurrente-rémittente en forme secondairement progressive en Normandie

Abstract : In the era of disease modifying treatments, little is known about conversion to the progressive phase (SP-MS) in relapsing-remitting multiple sclerosis (RR-MS) patients. The objective of the study is to identify the factors influencing the rate and the delay of a conversion to SP form within 11 years. The study was retrospective and bi-centered. The data was extracted from Observatoire Français de la SEP registry (Caen and Rouen university hospital). 629 patients were included in the « non-converter group » and 120 in the « converter group ». The « converter group » had-fewer women (65% vs. 74.4%; p=0.008) - a greater mean age at onset (35.45 +/- 8.83 years vs 28.66 +/- 9.49 years; p<0.001)- a higher number of patients who had > 2 or ≥3 relapses in the first two years (25.83% vs 21.30%; p=0.039 and 17.5% vs 11.13%; p=0.009 respectively) and a lower number of patients treated with first-line treatment (TPL) +/- associated with second-line treatment (24.17% vs 34.5%, p <0.001 and 11.66%. vs 15.42%, p = 0.029). The duration of the RR phase was correlated proportionally with the delay between the first and the second relapses (delay P1-P2) and with the delay in initiating treatment compared with the onset of the disease (R²=0.384; β=0.518; p<0.001 et R²=0.233; β=0.475; p<0.001) and was inversely proportional to the age at onset of the disease (R²=0.198; β=-2.443; p<0.001). Being older at the beginning of the disease, being male, and having had more than 2 relapses in the first two years of the disease are predictive of a transition to SP form at 11 years. Benefitting from a TPL is rather protective. The duration of the RR phase is correlated with the delay P1-P2.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-02321820
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Submitted on : Monday, October 21, 2019 - 3:11:57 PM
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Juliette Cuche. Facteurs prédictifs de passage de la sclérose en plaques récurrente-rémittente en forme secondairement progressive en Normandie. Médecine humaine et pathologie. 2019. ⟨dumas-02321820⟩

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