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Master Thesis

Hypervitaminémie B12 : facteur pronostic de morbi-mortalité de la personne âgée ?

Abstract : The dosage of vitamin B12 is not standardized, however, studies have linked high vitamin B12 levels to the presence of serious illnesses. The main objective was to study in a geriatric population the association between high vitamin B12 levels and the diagnosis of cancer or liver diseases considering the characteristics of the geriatric assessment. The secondary objective was to study the relationship between high vitamin B12 levels and the care pathway the following year. This observational retrospective study included all the patients hospitalized in the acute care for elders unit of the GHM between 01/01/2015 and 12/31/2016. Socio-economic, geriatric assessment and care pathway datas were collected from the medical report and after 1 year from their computerized medical file or by a telephone questionnaire. Patients were considered lost to follow-up when 1-year datas were not available. The main judgement criterion was the presence at 1 year of solid neoplasia, malignant blood or liver diseases. 397 patients were hospitalized, 25 were excluded because not tested. 233 files were analyzed because 139 were considered lost to follow-up. Univariate study showed that patients with high vitamin B12 levels had higher CIRS-G (p=0.01) and were frequently readmitted within the following year (p=0.03). Only the presence of cancer or liver disease remained significantly associated with high vitamin B12 levels considering the multivariate analysis (OR 6.23 95%CI [2.58;15.02]). In this population, high vitamin B12 levels were associated with the presence of serious diseases regardless of the geriatric assessment and appears to be a risk factor for readmission at 1 year, but not for mortality.
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Master Thesis
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Submitted on : Wednesday, October 23, 2019 - 11:53:25 AM
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Guillaume Lecomte. Hypervitaminémie B12 : facteur pronostic de morbi-mortalité de la personne âgée ?. Médecine humaine et pathologie. 2019. ⟨dumas-02328671⟩