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Master Thesis

Relation entre les perturbations du cycle veille-sommeil et la charge amyloïde cérébrale chez les sujets âgés

Abstract : Sleep disruptions have been associated with increased risks of developing cognitive disturbances such as mild cognitive impairment and Alzheimer’s disease. Recent studies suggest that accumulation of amyloid-beta (Aß) and sleep disruptions are interrelated. However, associations between brain changes underlying cognitive decline and sleep are still not completely understood. Aim: to objectively investigate sleep-wake disturbances in elderly individuals with subjective memory complaints with (A+) or without (A-) significant cerebral amyloid deposition.
Method: participants (68 cognitively healthy individuals with subjective memory complaint from the INSIGHT-preAD cohort) were asked to perform an ambulatory accelerometer-based assessment (7 consecutive 24-hour periods) to record their sleep quality, and were divided into two subgroups according to their levels of cerebral amyloid deposition (brain amyloid PET imaging). Participants also underwent a magnetic resonance imaging scan to assess their hippocampal atrophy.
Results: increased sleep latency, sleep fragmentation (Wake after sleep onset (WASO) score and awakenings) and worst sleep efficiency were associated with cerebral amyloid deposition. However, amyloid deposition was not region specific. Moreover, no association was found between sleep parameters and hippocampal atrophy.
Conclusion: in line with previous results, objectively-assessed modifications in sleep patterns were associated with higher level of cerebral amyloid deposition. This results reinforce the importance of preserving sleep quality in cognitively healthy elderly individuals.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-02341713
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Submitted on : Thursday, October 31, 2019 - 2:58:43 PM
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Eric Ettore. Relation entre les perturbations du cycle veille-sommeil et la charge amyloïde cérébrale chez les sujets âgés. Médecine humaine et pathologie. 2018. ⟨dumas-02341713⟩

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