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Master Thesis

Exposition professionnelle et troubles ventilatoires obstructifs chez les sous-mariniers

Abstract : Introduction: The empirical finding of obstructive lung disease (OLD) in young submariners in a context of worsening morbidity and mortality of occupational chronic obstructive pulmonary disease (COPD) led us to question the impact of the professional exposure of this special working environment. Material and methods: We conducted a retrospective, mono-centric, epidemiological and analytical study. The studied population accounted 277 submariners, divided into 3 seniority groups of 5, 10 and 15 years. The main objective was to measure the prevalence of OLD in the population. Secondary objectives were to compare the decline in forced expiratory volume in 1 second (FEV1) of our population with the expected charts results and to investigate (by a logistic regression analysis) the impact of different factors for the prevalence of TVO and for the early decline in FEV1. Results: All seniority combined, the prevalence of OLD in the course of career was 9%, 52% of them had an isolated impairment of distal flow. Only 7 subjects (2.5% of our sample) had an obstruction defined by FEV 1 / FVC <0.7 (comparable to French public health data). Prevalence of OLD was not significantly correlated with any of the studied factors, but a correlation trend could be observed with the smoking population (active and detoxed smoking)) as a risk factor for TVO (p = 0.06). The decrease in FEV1 in our sample was similar as expected by the charts. Premature decline in FEV 1 was correlated with age and seniority as well as with occupational exposure, but only for 5 to 10 cycles (1 cycle = 90 days of occupational exposure to the submarine atmosphere (OR = 3 ; CI95%[1,3-6,8]; p = 0.02). Conclusion: We did not demonstrate a causal link between the submariner profession and the prevalence of TVO. The trend towards an accelerated decrease in FEV1 should be confirmed by an exposed / unexposed study.
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https://dumas.ccsd.cnrs.fr/dumas-02413165
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Submitted on : Monday, December 16, 2019 - 10:10:11 AM
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Tanneguy Giraud Vinet. Exposition professionnelle et troubles ventilatoires obstructifs chez les sous-mariniers. Sciences du Vivant [q-bio]. 2018. ⟨dumas-02413165⟩

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