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Master Thesis

Étude observationnelle sur la couverture vaccinale incomplète et ses facteurs de risques chez les enfants de 2 ans vivant en Isère

Abstract : Background: Due to suboptimal vaccine coverage of infants in France, the number of mandatory vaccines has been extended from three to eleven in 2018. We aimed to determine the incomplete vaccination coverage in the two years-old children at the beginning of mandatory vaccination. Secondarly we want to determine the risk factors associated, to harvest the perceptions of parents concerning this mandatory vaccines and the reason of refusal or delay vaccination. Materials / methods: We conducted an epidemiological, descriptive, transversal and multicenter study. Some parents of 2-year-old children attending a consultation with a pediatrician, a general doctor, a doctor of social health center, or hospitalized in pediatric ward in Grenoble Hospital between May and September 2018 and living in Isère area, France, were proposed to fill an anonymous survey. Children were classified in 2 groups: complete vaccination schedule, or incomplete if at least one injection missed. Results: 525 children were included; 394 (75.0%) had a complete immunization schedule and 131 (25.0%) an incomplete one. 374 (72.6%) were followed by a pediatrician, 74 (14.4%) by a general practitioner, and 77 (15.0%) by a medical social doctor. There was a possible association between incomplete vaccination coverage and follow-up by a general practitioner (p<0.001) and home care (p=0.038). Conversely, follow-up by a pediatrician was significativly associated with a higher proportion of complete vaccine schedule (p=0.003). The main reasons of vaccine refusal from parents were the fear of adjuvant, of short-term sides effects (fever, pain…), and of long-term sides effects (such as multiple sclerosis after hepatitis B vaccination). The main reason for delaying immunization was that the child was sick when he was supposed to be vaccinated. Parents rated their confidence in vaccination 7.7/10 (+/-2). Furthermore, 55.4% of parents were favorable to the vaccine obligation; 61% would like to receive more information about vaccination, mostly through their doctor. Conclusion: We identify the rate of incomplete vaccination coverage and some potential risks factors. The reasons for refusal or delay vaccination will help to target the information in order to optimize vaccine coverage.
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Master Thesis
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Submitted on : Friday, December 20, 2019 - 10:13:28 AM
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  • HAL Id : dumas-02420707, version 1
  • PPN : 235259187


Hélène Rougier. Étude observationnelle sur la couverture vaccinale incomplète et ses facteurs de risques chez les enfants de 2 ans vivant en Isère. Médecine humaine et pathologie. 2019. ⟨dumas-02420707⟩



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