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Master Thesis

La leishmaniose amazonienne : à propos d’un cas. Revue de la littérature sur les leishmanioses à leishmania naiffi et leishmania lainsoni

Abstract : The amazonian cutaneous leishmaniasis (CL) in mainly associated with L.braziliensis and L.guyanensis. Other species are pathogenic for humans, such as L.naiffi and L.lainsoni, genetically the most divergent in the Viannia subgender, but less frequent and known.
We present a clinical case of CL caused by L.naiffi, acquired in French Guiana (FG), having persisted more than four years, and resistant to the Pentamidine treatment, fourth case of resistance to the initial treatment described.
We also collected the declared cases from the Leishmaniasis National Reference Center from Montpellier (except those form the Hospital of Cayenne), caused by L.naiffi and L.lainsoni, along with two cases provided by the University Hospital Center of Toulouse, to attempt to find a clinical picture and epidemiological specificities from these two species. We compared these data with those from the literature. For these two species, the infection countries are Brazil, French Guiana, Suriname, Peru, Ecuador, Colombia, to which is added Bolivia for L.lainsoni. There is no pathognomonic clinical criteria for these two species.
The phlebotomine sand flies found positives for L.naiffi are : Psychodopygus paraensis, P.squamiventrous, P.maripaensis squamiventris, Lutzomyia ayroza, P.davisi, P.hirsutus hirsutus, Nyssomya andezai, Lu.trapidoi, Lu.gomezi, Lu.trimula, Lu.tortura, Lu.longipalpis, Pressata dysponeta, P.carreira carreira. The nine banded armadillo (Dasypus novemcinctus) is the main host.
For L.lainsoni, his potential vectors are Lu.ubiquitalis, Lu.nuneztovari anglesi, Lu.longipalpis, Lu.trapidoi, Lu.evandroi, Lu.whitmani, Trichophoromyia brachipiga, Lu.auraensis.. The agouti paca (Cuniculus paca) is the main host.
CL due to L.naiffi and L.lainsoni do not show specific clinical characteristics allowing to differentiate them from other species. It is therefore necessary, for the best clinical management, to type all the Amazonian strains of CL. Moreover, there are many potential vectors, susceptible to make rises the number of CL cases due to L.naiffi and L.lainsoni. Indeed, FG is a French territory, where some of our military staff trains, and where many tourists go.
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Master Thesis
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Pascaline Bertrand. La leishmaniose amazonienne : à propos d’un cas. Revue de la littérature sur les leishmanioses à leishmania naiffi et leishmania lainsoni. Médecine humaine et pathologie. 2019. ⟨dumas-02431251⟩

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