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Master Thesis

Évaluation de la sécurité carcinologique du transfert de tissu adipeux autologue dans le cadre des mastectomies avec reconstruction mammaire immédiate pour cancer du sein

Abstract : Introduction: The safety of autologous fat transfer (AFT) has been controversial. The High Autority of Health in France in 2015 published precautionary measures for its use after radical mastectomy. Our objective is to evaluate the oncologic safety of AFT in a homogeneous population of patients who underwent a total mastectomy with immediate reconstruction for breast cancer. Methods: Our unicentric retrospective cohort study concerns a consecutive cases serie of total mastectomy with immediate reconstruction for breast cancer between 2007 and 2015 at the Institut Universitaire du Cancer de Toulouse. A patient group with a TTA performed in the 24 month after mastectomy was compared to a controlled group. Results: A total of 550 cases have been included and 136 of them (24.7%) underwent at least 1 fat graft transfer. Median follow up was 55,2 months (95% IC [52.9 ;57.7]). There was no difference for five years disease free survival between (DFS) the 2 groups : 92,32% [88.75;94.79] for the group without AFT and 90,91 % [81.01;95.78] for the AFT group (p = 0.957). In subgroups analysis, only patients with nodal involvement who underwent a fat graft transfer within 24 months, had a lower DFS: 69.15% than the patients without nodal involvement 92.46% (p=0.0351). Conclusion: Fat graft transfer used within the 24 months after total mastectomy for breast cancer and immediate reconstruction does not change disease free survival. Complementary analysis must be done in case of nodal involvement.
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Master Thesis
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Donia Omalek. Évaluation de la sécurité carcinologique du transfert de tissu adipeux autologue dans le cadre des mastectomies avec reconstruction mammaire immédiate pour cancer du sein. Sciences du Vivant [q-bio]. 2019. ⟨dumas-02464162⟩

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