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Master Thesis

Méthylation du promoteur de RASSF1 et tunneling nanotubes : intérêt clinique dans les cancers pleuro-pulmonaires

Abstract : By providing the first evidence of RASSF1A's involvement in intercellular communication via tunneling nanotubes (TnTs), this work reinforced RASSF1A's role as a tumor suppressor and metastasis agent. Hypermethylation of the RASSF1 promoter is a biomarker of cancers. Its identification in non-small cell lung cancer is of diagnostic and prognostic interest, allowing i) the screening of early lesions accessible to surgery and ii) the identification of a subgroup of patients likely to develop into a metastatic disease. Regardless of the expression of RASSF1A, the involvement of TnTs is reported in the carcinogenesis of many cancers, supporting the concept that their presence in a tumor has a prognostic impact. While no specific TnTs markers were reported, we have i) confirmed that connexin 43 and vimentin constitute a molecular signature of TnTs and ii) demonstrated in a cohort of 197 patients with malignant pleural mesothelioma (MPM) that vimentin overexpression was a factor in poor prognosis for overall and progression-free survival, reflecting the presence of TnTs in the MPM. Intercellular communication, via TnTs, is the basis for innovative therapeutic approaches, making it possible (unlike conventional treatments) to target all the cellular components of a tumor, to fight against tumor heterogeneity, responsible for the emergence of resistance cell clones selected by targeted therapies and responsible for recurrence.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-02464202
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  • HAL Id : dumas-02464202, version 1

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Bastien Jean-Jacques. Méthylation du promoteur de RASSF1 et tunneling nanotubes : intérêt clinique dans les cancers pleuro-pulmonaires. Médecine humaine et pathologie. 2019. ⟨dumas-02464202⟩

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