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Master Thesis

Les CAR T dans les hémopathies malignes : état des lieux, perspectives et mise en place dans la pratique clinique

Abstract : Chimeric Antigen Receptor (CAR) T-cell therapy is a form of immune therapy in which human T lymphocytes, genetically modified to express CAR receptors, are able to specifically target a tumor antigen and induce a cytotoxic response. CAR T-cells have been successfully used in clinical trials to treat various hematological cancers, and in August 2018 the European Medicines Agency (EMA) approved the two first-in-class medicinal products in the treatment of acute pediatric lymphoblastic leukemia and diffuse large B-cell adult lymphoma. However, although the results are encouraging, CAR T therapies come with serious toxicities. Cytokine release syndrome and neurotoxicity are serious life-threatening adverse events that require special management. Thus, this management of adverse reactions, but also early market access for CAR T cells and the lack of hindsight on long-term safety data have raised many questions from health, regulatory and economic authorities, as well as from healthcare professionals and patients. The specificity and originality of these therapies should lead to the implementation of new hospital pathways that might optimize the patient management, efficacy and tolerance of these immunotherapies.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-02475420
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Mélissa Beignon. Les CAR T dans les hémopathies malignes : état des lieux, perspectives et mise en place dans la pratique clinique. Sciences du Vivant [q-bio]. 2019. ⟨dumas-02475420⟩

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