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Master Thesis

Données cliniques autour de la fièvre Q aiguë à La Réunion : étude de cohorte rétrospective

Abstract : Introduction: Q fever is a neglected disease, C.burnetii is circulating in Réunion Island but acute Q fever clinical features and incidence remained unknown. The aim of this study was to report clinical and epidemiological data of acute Q fever in Réunion Island from 2004 to 2017. Materials/methods: Cases were retrieved from hospital databases using “Q fever” or “Coxiella burnetii” as search terms and enrolled in a retrospective cohort study in one of the four hospitals of the Island. Inclusion was based either on a positive Coxiella burnetii serology (defined as phase IgG II ≥ 200 and phase IgM II ≥ 50), or a seroconversion or a positive PCR on blood or serum of hospitalized patients. Results: Forty-two patients were included. Cumulative incidence was estimated at 9.3 per 100.000 inhabitants (95%CI: 6.4-12.1). Most common manifestations were pulmonary (n=26 with 45.2% pneumonia), digestive (n=11) and cardiac (endocarditis, n=2). Conclusions: Together with seroprevalence figures, these data suggest that Q fever reaches low to moderate endemic levels on Réunion Island. As previously reported, pulmonary symptoms are on the foreground.
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Master Thesis
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Submitted on : Wednesday, February 19, 2020 - 7:03:17 AM
Last modification on : Thursday, October 15, 2020 - 3:02:37 PM
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  • HAL Id : dumas-02484044, version 1

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Alexandra Aubin. Données cliniques autour de la fièvre Q aiguë à La Réunion : étude de cohorte rétrospective. Sciences du Vivant [q-bio]. 2020. ⟨dumas-02484044⟩

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