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Master Thesis

Déterminants du vieillissement dans l'infection par le VIH : étude SIMBAD

Abstract : Objectives. To assess skin, muscular, neurocognitive and bone aging markers in well-treated HIV-positive patients, compare them to that of the general population and seek to determine common mechanisms involved. Design. The SkIn, Muscle and Bone Aging Determinants (SIMBAD), a cross-sectional study from the ANRS-CO3 Aquitaine observational cohort. Patients were consecutively included between may 2012 and december 2013. Methods. Aging markers were evaluated by functional tests (Among others, Five-times Sit-To-Stand for locomotor function, Rey figure and Trail-making test for neurocognitive impairment, Bone Mineral Density (BMD) for bone disorders and Ur/Ue-ratio for skin properties), then compared to the general population of same age and sex when data were available in literature. Regression models were used to determine the association between alterations in these 4 domains and common causal factors. Results. Of 109 patients, 94% had undetectable viral load, 79,8% were men and median age was 51,6 years (interquartile range 46,6-61). Femoral neck BMD was lower for male patients <50, 50-60 and ≥60 years-old (0,763g/cm² ±0,098 standard-deviation (p<10-4), 0,733 ±0,101 (p<10-4) and 0,728 ±0,111 (p<10-2) respectively) but not for women. No difference was found for Five-times Sit-to-Stand-test, except for women who were slower (8sec ±1,9 SD, p<0,05). Rey Figure and Trail-Making B-test results were lower in patients <55 years-old (p<0,05 for both). In multivariate analysis, only older age was systematically and independently associated with altered locomotor and neurocognitive functions. No association was found between a well-conducted Mediterranean diet and aging markers. Conclusion. Our patients seem little affected by bone, skin, locomotor and neurocognitive aging, in a non-homogeneous way, and without repercussion on their overall abilities.
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Submitted on : Thursday, February 27, 2020 - 3:29:39 PM
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Inès Aureau. Déterminants du vieillissement dans l'infection par le VIH : étude SIMBAD. Sciences du Vivant [q-bio]. 2019. ⟨dumas-02493076⟩



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