Skip to Main content Skip to Navigation
Master Thesis

Explorations visuelles complexes et maladie d’Alzheimer prodromale : revue de la littérature et présentation de l’étude LYLO partie II

Abstract : Introduction: visuospatial dysfunction appears early in the Alzheimer’s disease course, and some studies have shown a visual exploratory strategy defect in Alzheimer’s Disease. The LYLO study has analyzed these complex visual explorations in subjects suspected of Prodromal Alzheimer’s Disease, in order to define their interests as diagnostic biomarkers. Materials and methods: transversal, multicentric, controlled study, analysing some complex visual exploration paradigms, registered with eye-tracking, on subjects having a Prodromal Alzheimer’s Disease (PAD), comparing their results with results of Alzheimer’s patients (AD) and healthy controls of the same age. Results: wenty-seven controls subjects (average MMSE 28,8), 29 Prodromal Alzheimer’s Disease patients (average MMSE 26,4), and 23 Alzheimer’s Disease patient (average MMSE 23,3) were included. No significant difference was found on none of the visual paradigms, between PAD subjects and healthy controls, neither between PAD subjects and AD patients. Discussion: none significant difference was identified concerning the PAD subjects. Several limitations of our study can partially explain this absence of significant difference (low power, recruitment and measurement biases), and so we can’t eliminate an eventual visuospatial dysfunction in PAD subjects, this defect being more and more described in the medical literature. Need to continue studies in order to find better diagnostic and prognostic biomarkers for the Alzheimer’s disease, permitting to define a target population to be able to develop efficient therapeutics for this public health issue.
Complete list of metadatas

Cited literature [208 references]  Display  Hide  Download

https://dumas.ccsd.cnrs.fr/dumas-02493372
Contributor : Médecine Ub <>
Submitted on : Thursday, February 27, 2020 - 5:10:08 PM
Last modification on : Thursday, March 5, 2020 - 5:19:04 PM

File

Med_spe_2019_Declerck.pdf
Files produced by the author(s)

Identifiers

  • HAL Id : dumas-02493372, version 1

Collections

Citation

Léa Declerck. Explorations visuelles complexes et maladie d’Alzheimer prodromale : revue de la littérature et présentation de l’étude LYLO partie II. Sciences du Vivant [q-bio]. 2019. ⟨dumas-02493372⟩

Share

Metrics

Record views

35

Files downloads

86