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Master Thesis

Épidémiologie et facteurs de risque du carcinome hépatocellulaire en Polynésie française : étude descriptive à propos des 139 cas diagnostiqués entre 2008 et 2017

Abstract : Introduction: the epidemiology of HCC in FP is poorly known. The primary objective of our study is to determine the incidence of HCC in FP and to describe the main risk factors for HCC in the last 10 years. Patients and method : We conducted a descriptive and retrospective study from January 1st, 2008 to December 31st, 2017, including all cases of HCC diagnosed and/or discussed during a multidisciplinary consultation meeting (MCM) at the general hospital of French Polynesia. Patients were included in the study from diagnostic data of the hospital patients, pathology department data and oncology MCM data. Results: 139 patients with HCC were included in our study according to the following eligibility criteria: histological confirmation (53%), radiologic Barcelona criteria (21%) or imaging-detected suspicious nodules with an alpha-fetoprotein level > 400 ng / mL (27%). The mean age at the moment of the diagnosis was 61 years with a male to female ratio of 4.6. The age-adjusted incidence rate for HCC in FP was 8.2 per 100,000 population in 2017, with a crude annual incidence rate of 43.1/100,000 in the Austral Islands archipelago. In FP, the most frequently observed risk factors were metabolic cause (65%), chronic hepatitis B (50%), and alcohol consumption (50%). 87% of the patients born in the Austral archipelago were chronic carriers of hepatitis B virus (HBV) and 100% of patients from this archipelago had been in contact with HBV. Conclusion: FP is a region with high incidence of HCC, especially in the Austral Islands archipelago. HCC in FP is frequently associated to metabolic syndrome, viral hepatitis B and chronic alcohol consumption. These results could contribute to improving the management of HCC in FP.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-02494738
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Andrée-Anne Lascols. Épidémiologie et facteurs de risque du carcinome hépatocellulaire en Polynésie française : étude descriptive à propos des 139 cas diagnostiqués entre 2008 et 2017. Médecine humaine et pathologie. 2019. ⟨dumas-02494738⟩

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