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Master Thesis

Impact de l’inflammation intestinale sur la qualité de vie et les symptômes digestifs chez les enfants atteints de mucoviscidose

Abstract : Introduction: the morbidity and mortality of cystic fibrosis is conditioned by pulmonary in-volvement, but other organs can be affected, including the intestine, which is the site of chronic inflammation. The short- and long-term repercussions of this inflammation are still poorly stud-ied. The main objective of this work was to evaluate the impact of intestinal inflammation on the quality of life and digestive symptoms of children with cystic fibrosis. Material and methods: bi-centric retrospective observational study in the Centers of Re-sources and Competences of the Mucoviscidose (CRCM) of Bordeaux and Toulouse, on 44 pa-tients children from 4 to 17 years who completed the questionnaires on the quality of life (Ped-sQLTM - Quality of Life Pediatric Inventory 4.0) and on the digestive symptoms (PedsQLTM - Gastrointestinal Symptoms Scales 3.0) and performed a concomitant assay of fecal calprotectin. Results: five (11%) patients were in the inflammatory group (fecal calprotectin ≥ 250 μg / g stool) and thirty-nine (89%) in the non-inflammatory group (≤ 250 μg / g). The overall score and sub-domains of quality of life were not significantly different between the two groups. Although the overall score for digestive symptoms was comparable between the two groups, some diges-tive symptoms were significantly more marked in the inflammatory group compared to the group without inflammation, including reflux (median 81/100 (IQR: 69; (IQR: 87; 100), p = 0.04), nausea (median: 75/100 (IQR: 75; 88) versus 100 (IQR: 94; 100), p = 0.01) and gases ( median: 50/100 (IQR: 39; 57) against 75 (IQR: 57; 93), p = 0.04). Conclusion: bowel inflammation may be associated with altered digestive symptoms, includ-ing nausea, reflux, and gas. Given the lack of specificity of these symptoms, the measurement of fecal calprotectin can help the practitioner in this diagnosis.
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Contributor : Bu Carreire Université de Bordeaux <>
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Martin Addra. Impact de l’inflammation intestinale sur la qualité de vie et les symptômes digestifs chez les enfants atteints de mucoviscidose. Médecine humaine et pathologie. 2019. ⟨dumas-02505884⟩

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