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Master Thesis

Association entre hypertension, traitements anti-hypertenseurs et démence : rôle des biomarqueurs des maladies des petits vaisseaux et des biomarqueurs de la maladie d’Alzheimer

Abstract : High blood pressure is an important cardiovascular risk factor and there is mounting evidence to suggest its involvement in the development of small vessel disease of the brain and its potential role in the development of dementia. The biological mechanisms are poorly understood and many questions remain about the involvement of cerebrovascular abnormalities in the pathophysiology of Alzheimer's disease, which is the leading cause of dementia. The results of an analysis of the Memento cohort data suggest an impact of high blood pressure on cognitive abilities when uncontrolled. Other studies may also have shown or hypothesized an interest in controlling blood pressure through the use of antihypertensive drugs to reduce the risk of dementia. The management of high blood pressure in France has significant shortcomings in terms of screening and compliance. Further studies are needed to determine whether optimising this management and blood pressure control could be an interesting strategy for dementia prevention.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-02944213
Contributor : Frédérique Gambade <>
Submitted on : Monday, September 21, 2020 - 12:13:58 PM
Last modification on : Wednesday, October 14, 2020 - 4:20:15 AM

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  • HAL Id : dumas-02944213, version 1

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Jérémie Lespinasse. Association entre hypertension, traitements anti-hypertenseurs et démence : rôle des biomarqueurs des maladies des petits vaisseaux et des biomarqueurs de la maladie d’Alzheimer. Sciences du Vivant [q-bio]. 2020. ⟨dumas-02944213⟩

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