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Master Thesis

Étude de la dispersion des particules lors de l'administration d'un médicament par aérosols

Abstract : Introduction: Health care workers are at risk of contamination during epidemics of respiratory virus such as SARS-CoV-2. Spontaneous or induced aerosolization of viral particles is an important mechanism of transmission. Inhaled drug treatment may produce important quantity of aerosolized droplets. We aim to compare particles’ scattering during treatment either by jet nebulizer or by pressurized metered-dose inhaler with holding chamber. Methods: 2 groups of three healthy volunteers each were investigated: one with jet nebulizer receiving 6mL of 0,9% sodium chloride and one with pressurized metered-dose inhaler with spacer receiving 1000µg of salbutamol. Inhalation lasted 10min followed by a wash-out period. Measure were done by laser counting. Results: In the nebulizer group, a maximum increase was measured at 9min of 0,5µm and 1µm particles (+10807% (IC95% 10720-10893) and +42720% (IC95% 39021-46419), respectively) without return to initial position after wash out period. In the inhaler group, we observe a peak of +219% (IC95% 159-279) with a return to the initial concentration at the beginning of the wash out period. Particles spread in all directions until 1m in the inhaler group. Conclusion: Inhaler and inhalation spacer reduces particles’ scattering into time and space compared to a nebuliser. Contamination risk of health care workers may be limited by using pressurized metered-dose inhaler with inhalation chamber.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-02944918
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Submitted on : Monday, September 21, 2020 - 6:31:21 PM
Last modification on : Wednesday, October 14, 2020 - 4:13:05 AM

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Arthur Petitjean. Étude de la dispersion des particules lors de l'administration d'un médicament par aérosols. Médecine humaine et pathologie. 2020. ⟨dumas-02944918⟩

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