Skip to Main content Skip to Navigation
Master Thesis

Étude des lésions secondaires au papillomavirus humain selon le statut vaccinal des patientes adressées en consultation de colposcopie au CHU de Bordeaux.

Abstract : Introduction: cervical cancer is a global public health problem, despite the development of effective vaccines, notably due to insufficient vaccine coverage, where, for example, in France, it has not exceeded a third of the target population in 2018. The main objective of our study was to show that the HPV histological lesions, encountered in young women referred for colposcopy consultation at Bordeaux University Hospital, were less serious in the vaccinated women compared to those not vaccinated. Method: we conducted a monocenter observational analytical study, exposed- unexposed of the historical cohort type, with histological prospective data, at Bordeaux University Hospital, from September 2018 to November 2019. Results: vaccinated women had statistically fewer high-grade histological lesions, 11,4%, compared to almost a third of unvaccinated women (31,8%), p=0,019. Vaccinated women were 3,5 times less likely to develop high-grade cervical injury than unvaccinated women (OR = 0,28, 95% CI: 0,09-0,84, p=0,026), or a relative risk reduction of 72%., all other things being equal. In the subpopulation of women with HPV typing, there was no statistically significant difference between vaccinated and unvaccinated patients in the distribution of the different types of HPV (p=0.065), nor more particularly for HPV 16 and 18 (4,8% vs 27,9%, p=0,067). Conclusion: HPV vaccines are undoubtedly effective and there is a need to increase their coverage in order to be able to eliminate cervical cancer.
Complete list of metadatas

Cited literature [274 references]  Display  Hide  Download

https://dumas.ccsd.cnrs.fr/dumas-02945406
Contributor : Médecine Ub <>
Submitted on : Tuesday, September 22, 2020 - 11:47:05 AM
Last modification on : Wednesday, October 14, 2020 - 4:20:13 AM

File

 Restricted access
To satisfy the distribution rights of the publisher, the document is embargoed until : 2021-06-11

Please log in to resquest access to the document

Identifiers

  • HAL Id : dumas-02945406, version 1

Collections

Citation

Jeanne Le Guevel. Étude des lésions secondaires au papillomavirus humain selon le statut vaccinal des patientes adressées en consultation de colposcopie au CHU de Bordeaux.. Sciences du Vivant [q-bio]. 2020. ⟨dumas-02945406⟩

Share

Metrics

Record views

9