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Master Thesis

Influence du virus Zika dans le devenir fonctionnel au long cours des patients atteints d'un syndrome de Guillain-Barré

Abstract : BACKGROUND: Zika infection is often asymptomatic, but may be responsible for neurological conditions such as Guillain Barré Syndrome (GBS). We conducted a comparative study to determine if Zika was a poor prognosis factor in the functional outcome of GBS. METHODS AND FINDINGS: We carried out an observational study at the University Hospital Center of Guadeloupe, comparing patients with GBS linked to Zika (Zika+) and not linked to Zika (Zika-). The primary endpoint was the impact of the GBS on the ONLS (Overall neuropathy limitation scale) functional score at 36 months. The profitability of the walk ("Walk Ratio"), the spatio-temporal parameters of walk and stability were collected on a stabilometry platform and a Zeno® walking platform. RESULTS :We included 20 Zika+ patients and 13 Zika -patients. Patients who developed GBS related to Zika+ had less time spent in rehabilitation (median 37 days versus 110 days for Zika-). A large number of patients (91%) had neurological sequelae, the most common of which were paresthesias (63%), bilateral facial paralysis (40% Zika+ versus 15.4% Zika-, p=0.245). Half of the patients had an ONLS disability score >1 (50%, n=10 Zika+ and 46.2%, n=6 Zika-, p=0.829). Patients who developed GBS after Zika had no different functional scores than other patients. The gait profitability, normal in the Zika- group, was impaired in 20% of patients in the Zika+ group. The frontal and sagittal instability, who increased with open eyes, persisted in 81% of cases. CONCLUSION: Zika does not promote the persistence of neurological sequelae away from GBS. Walking and Balance platforms allow for the detection of certain motor disorders.
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Master Thesis
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Méline Marie Abraham. Influence du virus Zika dans le devenir fonctionnel au long cours des patients atteints d'un syndrome de Guillain-Barré. Médecine humaine et pathologie. 2019. ⟨dumas-02948603⟩



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