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Master Thesis

Quantitative measurement of total lung vascular volume by computed tomography in COPD patients: correlation with clinical events and biological data

Abstract : To investigate the relationship between quantitative CT measurements of pulmonary vessel volume and number with clinical outcome, serum biomarkers of inflammation and oxidative stress, and lung function, in COPD patients. Total lung vascular volume (TVV), TVV normalized to body surface area (TVVn), total number of vessels (NoV) and number of vessels <5 mm² cross section (NoV5) were measured using a custom software on unenhanced thoracic CT scans. Our cohort included 62 COPD patients (63.8 years [59 ; 69.6]; 74% male) with the following distribution: GOLD I n=8 (12.9%), GOLD II n=39 (62.9%), GOLD III n=10 (16.1%) and GOLD IV n=5 (8.1%). Clinical outcome data for all-cause hospitalization, lung infection, exacerbation, and intensive care unit hospitalization, were recorded up to 5 years following chest CT. Lung function, arterial blood gas and high sensitivity plasma C-reactive protein (hsCRP), fibrinogen, thiols and serum antioxidant capacity were measured. TVVn significantly correlated with pulmonary infection (OR = 1.06 [1.01; 1.12] p = 0.02) and hospitalization (OR = 1.06 [1.01; 1.12] p = 0.01), HsCRP (β = 3.12 (0.84) p = 0.001) and inversely correlated with total serum antioxidant capacity (β = -90.21 (41.38) p = 0.03). There was no correlation between NoV and NoV5 with clinical outcome. Our study suggests that quantitative CT measurements, particularly TVVn may help predict clinical outcome in COPD patients, and merit further investigation as a surrogate imaging biomarker.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-02954622
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Submitted on : Thursday, October 1, 2020 - 11:06:44 AM
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Cevdet Ozcelik. Quantitative measurement of total lung vascular volume by computed tomography in COPD patients: correlation with clinical events and biological data. Human health and pathology. 2018. ⟨dumas-02954622⟩

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