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Master Thesis

Étude de l'implication de la protéine RhoB lors de l'activation des lymphocytes T gamma9 delta2 dans un modèle de cancer du poumon

Abstract : Immunotherapy is a new therapeutic approach to stimulate the patient's immune system to strengthen its defenses against cancer cells. There are different types of immunotherapies, including adoptive cell transfer, which has been the subject of numerous studies. In this approach, Vγ9Vδ2 T cells are interesting candidates since they have numerous effector functions without the need for restriction by MHC molecules. These unconventional T cells are major players in anti-tumor immunity. They are activated by non-peptide antigens called phosphoantigens (PAgs), which can be accumulated in situ by pharmacological molecules such as aminobiphosphonates. The activation of Vγ9Vδ2 T cells is mediated by various proteins, in particular the butyrophilins (BTN) BTN2A1 and BTN3A1, forming a complex around the Vγ9Vδ2 TCR and allowing recognition of PAg. During the activation, other actors operate to regulate this mechanism. Thus, the small GTPase RhoB would coordinate the intracellular mobility of BTNs, promoting the activation of Vγ9Vδ2 T cells. However, the clinical use of Vγ9Vδ2 T cells is complex and their action remains limited. It is therefore necessary to deepen the understanding of the involvement of RhoB in this mechanism in order to improve the effectiveness of immunotherapies using Vγ9Vδ2 T cells.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-02959076
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Submitted on : Tuesday, October 6, 2020 - 2:39:24 PM
Last modification on : Saturday, October 10, 2020 - 3:09:08 AM

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Chloé Laplagne. Étude de l'implication de la protéine RhoB lors de l'activation des lymphocytes T gamma9 delta2 dans un modèle de cancer du poumon. Sciences du Vivant [q-bio]. 2020. ⟨dumas-02959076⟩

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