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Master Thesis

Trajectoires de l’apathie et de la dépression dans le cadre du trouble cognitif léger

Abstract : Apathy and depression are two early behavioral symptoms in Alzheimer’s disease and related disorders, that often occur before the onset of cognitive decline and memory disturbances. Both have been related to increased risk of conversion toward dementia.
Objective: to assess both apathy and depression trajectories, using the Neuropsychiatric Inventory for caregiver (NPI) and clinician (NPI-C), among individuals diagnosed with subjective cognitive decline (SCD) and followed up over a 60-month period and among individuals that converted toward dementia, using inputs from the French Memento Cohort.
Results: Among individuals with SCD (n=2,323), levels of apathy and depression were low and did not evolve significantly over a 60-month period, despite a trend in apathy increase as of month 24. Regarding SCD individuals that converted to dementia with the 60-month period, the prevalence of depression remained globally steady whereas levels of apathy increased.
Conclusion: apathy and depression have different trajectories among individuals with SCD and apathy alone is more likely, compared to depression, to be associated with conversion to dementia.
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Master Thesis
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Contributor : Bibliothèque Universitaire de Médecine Nice <>
Submitted on : Thursday, October 15, 2020 - 5:37:44 PM
Last modification on : Saturday, May 1, 2021 - 3:15:44 AM


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  • HAL Id : dumas-02968501, version 1


Anamaria Bogdan. Trajectoires de l’apathie et de la dépression dans le cadre du trouble cognitif léger. Médecine humaine et pathologie. 2020. ⟨dumas-02968501⟩



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