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Master Thesis

Impact pronostique d’un contingent macrotrabéculaire dans le carcinome hépatocellulaire

Abstract : A novel histological subtype of hepatocellular carcinoma (HCC) designated as "macrotrabecular-massive" was recently identified. It is an aggressive form of HCC which is associated with a poor prognosis. The aim of our study is to evaluate the impact of macrotrabecular foci (<50%) on the prognosis of patients with HCC treated by surgical resection. We retrospectively included 170 HCC surgical samples from patients treated by surgical resection. Histological slides were reviewed by two pathologists and the percentage of macrotrabecular architecture was evaluated. Two subtypes were defined: HCC with foci of macrotrabecular architecture (between 5 and 50%) and HCC with no macrotrabecular architecture (<5%). The macrotrabecular massive subtype were excluded. The main clinical and biological features were recorded at baseline. Clinical endpoints were death and overall recurrence. HCC with foci macrotrabecular architecture were identified in 21% of the whole cohort. It was associated at baseline with known poor prognostic factors (tumor size, AFP level, poor differentiation and vascular invasion). Multivariate analysis showed that HCC with foci of macrotrabecular architecture was an independent predictor of death (OR 2.1 (0.94-4.69), p=0.06). However, there was no impact of foci of macrotrabecular architecture on the recurrence rate. In conclusion, our study demonstrates that CHC with foci of macrotrabecular architecture are characterised by a dismal clinical course.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-02990815
Contributor : Université Paris Descartes - Scd <>
Submitted on : Thursday, November 5, 2020 - 5:12:24 PM
Last modification on : Wednesday, February 17, 2021 - 3:19:23 AM

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  • HAL Id : dumas-02990815, version 1

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Justine Cohen. Impact pronostique d’un contingent macrotrabéculaire dans le carcinome hépatocellulaire. Médecine humaine et pathologie. 2019. ⟨dumas-02990815⟩

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