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Master Thesis

Étude de la dynamique de Let-7 par RMN très hauts champs

Abstract : Let-7 is a non-coding micro-RNA involved in various cellular mechanisms. It interacts with other RNAs as HMGA2, TRIM71 or LIN28, and its deregulation implies cancers. In order to understand how this micro-RNA works, it is important to know the interactions between him and its different partners at an atomic scale. For that, nuclear magnetic resonnance or NMR represents a powerful tool for molecular dynamic studies. Indeed, it allows us to observe various movements from picoseconds to seconds. Extraction of dynamic parameters from spectra allows us to characterize and describe existing interactions between two molecules. From sample production to spectra resolution, we will present in this dissertation our approach to study Let-7 dynamic and present our first results about its production and its analysis with NMR.
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Master Thesis
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Submitted on : Thursday, December 3, 2020 - 3:13:11 PM
Last modification on : Friday, February 19, 2021 - 3:29:30 AM
Long-term archiving on: : Thursday, March 4, 2021 - 7:22:43 PM


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  • HAL Id : dumas-03038538, version 1




Maxime Borret. Étude de la dynamique de Let-7 par RMN très hauts champs. Sciences du Vivant [q-bio]. 2020. ⟨dumas-03038538⟩



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