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Master Thesis

Les kératites infectieuses : manifestations cliniques et prise en charge

Abstract : Infectious keratitis is a serious eye disease that represents one of the world's leading causes of visual impairment that can evolve into blindness, particularly affecting marginalized populations. We notice an increase in this infection in developed countries, mainly due to the wearing of contact lenses. In the clinical practice, most commonly bacterial, herpetic, mycotic and amoebic keratitis occurs. Due to the potentially serious rapid development of infectious keratitis, rapid and correct diagnosis as well as early therapeutic management is essential. While in vitro culture remains the prevailing diagnostic tool, newer techniques such a confocal microscopy in vivo, molecular methods, new generation sequencing, holds the potential for early and accurate diagnosis even for organisms that are difficult to culture by conventional methods. The aim of this bibliographic thesis is to explore the literature in order to determine the different therapies existing today for the various etiologies and future directions to improve the management of this pathology and the complications directly threatening visual acuity and patient quality of life. It is noted in the literature that in the event of early diagnosis and initiation of topical treatment, most cases of infectious keratitis are recover successfully. However, in some cases surgical treatment may be necessary such as penetrating keratoplasty, amniotic membrane transplantation or crosslinking therapy. It is concluded that future strategies to reduce the morbidity associated with infectious keratitis are likely to be multidimensional with adjuvant therapies aimed at modifying the immune response to infection holding the greatest potential to improve clinical outcomes.
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Master Thesis
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Submitted on : Tuesday, January 5, 2021 - 9:19:17 AM
Last modification on : Friday, January 8, 2021 - 3:26:53 AM


SEMAHA Sabine. Thèse d'exerci...
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  • HAL Id : dumas-03096612, version 1


Sabine Semaha. Les kératites infectieuses : manifestations cliniques et prise en charge. Sciences pharmaceutiques. 2020. ⟨dumas-03096612⟩



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