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Master Thesis

Impact pronostique du CD43 dans le lymphome du manteau

Abstract : CD43 expression is inconstant in mantle cell lymphoma (MCL). However, its implication on survival has not been highlighted. A retrospective study from 2014 to 2019 was carried out on 42 patients with MCL at the teaching hospitality of Caen in order to perform CD43 impact on overall survival (OS) and progression-free survival (PFS). This study is based on the quantification of the intensity of CD43. It’s more developed in lymph node rather than blood (371.7 and 174.3 respectively, p= 0.038). CD43 positivity was admitted for an MFI (mean of fluorescence) greater than 300 (peripheral blood) and 500 (lymph node). In peripheral blood, despite reduced survival for patients with CD43+, OS and PFS are not significantly different. In lymph node, the CD43’s positivity would be linked to a less favorable OS ((5.11 vs 1.35) and PFS (4.70 vs 1.35), p= 0.033. In this study, the positivity of CD43 would be a marker of poor prognosis, confirmed by a multivariate analysis. Due to the small size of this study, these data must be confirmed by a larger cohort.
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Master Thesis
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Submitted on : Friday, January 8, 2021 - 12:43:46 PM
Last modification on : Thursday, February 25, 2021 - 3:24:07 AM
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  • HAL Id : dumas-03103760, version 1


Alexandre Matte. Impact pronostique du CD43 dans le lymphome du manteau. Sciences pharmaceutiques. 2020. ⟨dumas-03103760⟩